Sunday, April 12, 2020
Thursday, March 1, 2012
Breath
N.B. This post may be considered, um, politically incorrect. Let's just consider it in a clinical context.
I am jewish, well, my mitochondria is. And if I'm right, my oral microbiome, rather, my breath, is as well. I call it "Jew Breath". It resembles mothballs(note: this is not my breath all the time, only occasionally!). I've noticed it a lot at Temple and had it independently confirmed by an old jewish roommate:
"You know what I'm talking about" I said to A. "Jew Breath is real!". A put his face in his hands, smiled, and nodded slowly, admitting the painful truth. I could smell it on him too.
As an SGU'er, with my school's majority Indian population, I also noticed among some a certain "Indian Breath" (or more offensively: Desi Breath). I can't quite put into words what it smells like, but I prefer it to Jew breath. Anyways, a fellow (caucasian/goyim) med student who is dating an Indian women actually had that breath... which means either the smell is not associated with the subcontinent OR she transferred some of her oral flora to him through excessive make out sessions (how long and how many remains a subject for further study).
There is some clinical relevance to this, however. Analyzing the myriad microbiomes of the gastrointestinal tract is a hot research topic,implicated in everything from Chron's disease, type 1 diabetes, failure of anastomeses in surgery (from a grand rounds lecture pre-pub) to development of pancreatic cancer. And it turns out, some research has found a difference in the oral microbiome of different ethnicities.
So maybe there is something to Jew Breath after all...
Posted by JP at 8:28 AM 0 comments
Labels: biodiversity, clinicals, microbiome, research, SGU
Sunday, January 29, 2012
Maple Syrup
The tapping of trees for maple syrup was practiced in north america for thousands of years before the arrival of the immigrants. The French adopted its use early on and it's a tradition that has had a noticeable impact on the St. Lawrence River valley. Maple syrup also has a history as one of the earliest examples of socially responsible purchasing. Slavery lords of the south produced much of the sugar in the United States in the early to mid 19th century. For abolitionists, maple syrup became an alternative source of sweetener to divert funds from the economic clout of the slave owners, as were other agricultural products similarly boycotted as part of the Free Produce Movement. Interestingly, the Free Produce Movement began in the 1790's and lasted until the 1850's. Somewhat parallel to today with fair-trade and organic goods, the "Free Produce" products never were able to compete economically with slave labor products. Though, one could say "Free Produce" is finding a more enlightened market in the 21st century, ultimately people have to value their ethics of human rights and environmental responsibility more than saving money...
Posted by JP at 4:05 PM 0 comments
Labels: environment, history, maple syrup, socially responsible
Tuesday, January 24, 2012
Round, Cut, Eat, Sleep
Alarm slap at 4:45, got 20 miutes to get ready. It starts with a cold bike ride through the dark park, and suddenly I have coffee and Ins & outs. The parade of patients then flies by, soon back in the OR and the ritual scrub in begins. Inside the abdomen now, presurized camera port view - like a reverse submarine periscope. Hiding spleen and adherant umbilicus, don't forget the internal hernias. We're out and grabbing an Oxygen tank, wake up - you did well, well your GIT did, now it's up to a duel b/w your WBCs and disturbed microbes. Pass off at PACU, go grab something for $3.26 - surgery makes you hungry. But at the end of the day sometimes, you're more tired than hungry - wake up at midnight wiht the light on, turn it off - rinse and repeat.
Thursday, January 12, 2012
Competitive Specialties
Entering clinicals, I never expected to like the more "procedural" specialties. But ever since I scrubbed into my first C-Section in OBGYN, I've been drawn to the OR. The excitement, the atmosphere, the sense of accomplishment, the work of having a few, long, nice projects to work on for the day and the ability to see a difference in a patient after surgery are all very attractive to me. I can see that much of my pre-clinical work was also project oriented, even if it had little to do with surgery.
If only things were so simple. I decided to take SGU up on there clinical academic advising services (something I made good use of in basic sciences with the great Dr. DB). I sent in my CV, GPA, Step 1 and goals of matching in Surg or OBGYN. I will say Dr. PB (the clinical advisor) gave me some needed advice and gave a great critique of my resume. But he basically said I have less than a coin flip's chance of matching in either specialty. Not a 0 chance, but not great either. It's tough news, but I'm thinking about what I can do to change my chances and think hard about what I like about the OR.
But it got me angry and thinking about WHY certain specialties have cut offs. Does someone need to be that much smarter to go into General Surgery than to go into Family Medicine? Is the academic training of Dermatology really more broad than Primary Care?
From my experience in medicine: No. In fact, general practice is in many ways more challenging intellectually - you really have to know the subtle signs of sickness to catch the deadly diseases early among the sea of worried well. No, there is something else at play, as DJ Shadow once alluded to...
The most competitive specialties pay the best. Lifestyle is a part of this, which is why EM - a midrange compensation - is becoming highly sought after. This is not surprising if one is a cynic, but it's disheartening if one is kinda typical on stats paper but wants to follow their interests and make a difference in a field. We live in a capitalistic society, so I guess I shouldn't expect things to be different - it's just always startling when the brutal reality of it stares you in the face. I just wonder what the distribution of Derm vs. Family vs. Surgery vs. Psych would be if all of them paid the same and had the same hours. And what that would do to the delivery of healthcare in this country. Considering how many physicians I've hear complaining about compensation cuts, I'm guessing it would be a bit different than today :)
F/U post comparing specialty distrubution in other healthcare systems (europe, canada, india) to follow...
Posted by JP at 4:38 PM 2 comments
Tuesday, September 6, 2011
Fully formed
(Paul) Farmer entered Harvard med school in the fall of 84. He was only twenty-four. He told me once, "I was fully formed at twenty three." He meant, I think, that by then he had his philosophy and worldview in order, and he knew he wanted to marry them to action..."
From Mountains Beyond Mountains
How many students enter med school with an independently formed world view?
Sure, many have goals, mainly around specialty, lifestyle, etc. But in many ways the med school admissions process selects more for students who can have the world view of their institution imparted onto the next generation of doctors than for those who have their own ideas about what they want with medicine. Ideas that, in many cases, take time away from the pre-med grind in order to formulate.
I am seeing the validity of my original goals with medicine the more I get into the grey fog of action, indepenence, and socio-politics that is clinical practice. A validity that was much harder to see in the cold facts of mcq memorization that was basic sciences.
Posted by JP at 2:06 PM 0 comments
Labels: clinicals, paul farmer, pih, reading
Thursday, August 25, 2011
This is clinicals
Have reached the stage of exhaustion where I am a complete neurotic, overly sensitive, giggling monstrosity. I am so toasted yet still oddly wired and excited to get up and go to the hospital and explore brooklyn and i dont even know. This is clinicals.
Posted by JP at 5:25 PM 2 comments
Friday, April 29, 2011
When Normal is Abnormal
In the last week of my Introduction to Clinical Medicine course, we had a middle aged women patient with hypothyroidism. She had a bought with Grave's disease and ended up with radioactive iodine therapy which, though it cured her hyperthyroidism, left her with hypothyroidism. She was later put on levothyroxine but ever few years they needed to increase the dose. I remember asking if this was typical to our clinical professor that day, Dr. R, and he said that this is quite common with hypothyroid patients.
--
My friend B also has hypothyroidism. B also developed hypothyroidism as a result of radiation, but this was for her Hodgkin's Lymphoma, which she successfully beat. B initially went undiagnosed until her Oncologist, and the best Doc she's ever had, noticed her sweating too much when she came in once, and immediately ordered a TSH test. Since then she was placed on 50ug of Levothyroxine and her TSH was typically around 1.1 (reference range 0.4 - 5, though there is some debate about this).
Sir Charles Robert Harington, discovered the structure and synthesis of levothyroxine
Over the past year or so, B started to notice her hair falling out. At first she thought it was due to two surgeries she had within a few months of each other (both for unrelated conditions). Her previous Endocrinologist took a job in another city and so she saw a new one at a prestigious university last June. After looking at her TSH (2.2) and examining her rather quickly, she told her "your hair is not going to all fall out" and rather rudely dismissed her concerns.
Dismayed by this for a while, B continued to watch her hair fall out for the next several months and then started to get some painful acne. After this she made an appointment with a Dermatologist in November. Her PCP signed off on the referral, though he didn't have much insight into her hair loss either. The Dermatologist examined her and drew some blood. Before she got any results back she prescribed spironolactone, presumably for its anti-androgenic effects to counter the acne and hair loss. She ran her own tests and noticed she had a slightly elevated aldosterone, called B and told her to take the spironolactone.
The spiro at first stopped the hair loss but didn't induce much regrowth. After a month on it without any complaints, the Derm doubled the dose to induce regrowth. Within a few weeks B started to notice some strange side effects, though not entirely uncommon. She stuck through this (she is a very compliant patient) but then started to just get plain lethargic over the end of winter and into spring. She also stopped working out and couldn't seem to keep her apartment organized. B thought perhaps it was the long, cold winter but then she started to get salt cravings and gain some weight. Again, possibly spiro side effects, at least the salt craving.
Since spiro is a potassium sparing diuretic, one must be careful about potassium intake. One day in March, B ate a bit too much broccoli and appeared to get symptoms of hyperkalemia. It could also have been just bad broc, but after that she was scared off eating anything with a lot of potassium - cutting out some of the fruit staples of her diet such as bananas and juices. After this, she started to feel insatiable hunger and, as a cancer survivor, started to get paranoid about the constellation of symptoms of tired, hunger and generally feeling ill.
Just this past week she had her yearly check up with her Oncologist. After reporting how she felt to the interns and doing some blood work, they came to a rather obvious conclusion: B needed to increase her dose of levothyroxine. It turns out that at this appointment, her TSH had risen to 3.3, while still in the "normal reference range", her oncologist knew her history and that B's typical range for proper thyroid treatment was a TSH of around 1. She prescribed a dose of 75ug and explained that her hair loss, weight gain, and lethargy were all likely due to the hypothyroidism.
--
Looking back on this, there are a few interesting lessons. First, the reference range does not always tell the whole story. References ranges are in fact based on the population mean for a lab value, +/- 2 standard deviations. This helps us see pathological outliers, but it doesn't always tell the most accurate story for an individual. It reminds me of another story where a fellow med student, and former nurse, said someone could have a blood sugar of 40 be not outrageously low (though we're taught <60 is low) because he could just be someone who has low sugar. While I have not had enough clinical experience to appreciate this, it seems to make sense and was certainly analogously true for B.
Also, I know my own personal clinical judgement got warped when trying to help B figure out what was wrong. Makes me wonder how much physicians can really get emotionally vested in their patients before we start to see what we want rather than what is really taking place.
However, the most disturbing aspect of this whole endeavor was the fact that 3 separate, board-certified physicians completely missed what was going on. Not only were her symptoms dismissed (endocrinologist), completely missed (primary care doc) but she was also misdiagnosed and given an unnecessary treatment (dermatologist). A year of distressingly losing hair and the psychological consequences of that, gaining weight, rising blood lipids and also some inflammation on top of it all, could have been avoided if someone had just put together her symptoms with her #1 chronic condition and what is "normal reference range" for her, individually.
It raises many questions about the coordination of care, the role of medical records, and even the attentiveness (perhaps overworked, perhaps not) of the physicians in our US healthcare system. I just wonder how typical such cases truly are... and will certainly do my best to keep this in mind on my clinical rotations later this year.
Wednesday, April 27, 2011
Science 2.0
Damn you wikipedia!
I tried to remember what the name of the social networking researchers was called, only to find out there are several competitors that look interesting. ResearchGate was the one I was looking for, but then I found Academia.edu, epernicus, and then SciSpace.com. Now instead of happily signing up for ResearchGate, I want to look into each of these but don't have the time. So I will likely forget about it for another few months and repeat the same process. Unless I can remember this blogpost...
Add these to my neglected accounts on Medpedia and LinkedIn, as well as that whole inspiration exchange thing AMSA has, and we're getting into serious social networking overload here.
Ok back to facebook.
Posted by JP at 5:29 PM 0 comments
Labels: research, social networking, Term 5, wikipedia
Sunday, April 24, 2011
The Unconventionalists
Nature (the journal) is running a theme this week on the future of the PhD. Some interesting convos going on in the comments over there, and I even found another cool book to read from it.
One blog post at the nature network stuck with me though. This scientist-in-training reflected on her unconventional aspirations and how others would react:
In the cover of my unspoken reality, I dared to be disappointed with my top 5 academic institution, where to entertain creative ideas of a non-traditional career in the sciences was to be exiled from the class of 'serious' scientists. A lullaby for a weaker child of chemistry. Enjoy your dreams of a lesser biology. She couldn't make it in the big leagues, they'd say. So I hide my dreams of translating science, colorful pages lost in a library of dull covers with obscure, impossible-to-pronounce titles. Surface Plasmon Resonance Series - Nanotechnology-based Sensors. Professor, here is my secret: such a library of science begs translation for the curious non-scientists. Thrilling stories of scientific discoveries that will make our fellow non-scientists as curious as we. Put me in coach. The only thing I know better than science, is the art and draw of language.
As someone with a non-traditional trajectory in medicine, I can hear her picturing others thinking "what are you doing here"... and have had others tell me the same thing. It can be frustrating at times, but I love her "Professor, here is my secret" line, it really captures how I feel when people ask my planned specialty or wonder how what I have planned with medicine...and why I persist on reading fiction in the middle of the semester. And then I run across quotes like these and feel a little bit better about it:
I cannot serve as an example for younger scientists to follow. What I teach cannot be learned. I have never been a '100 percent scientist.' My reading has always been shamefully nonprofessional. I do not own an attaché case, and therefore cannot carry it home at night, full of journals and papers to read. I like long vacations, and a catalogue of my activities in general would be a scandal in the ears of the apostles of cost-effectiveness. I do not play the recorder, nor do I like to attend NATO workshops on a Greek island or a Sicilian mountain top; this shows that I am not even a molecular biologist. In fact, the list of what I have not got makes up the American Dream. Readers, if any, will conclude rightly that the Gradus ad Parnassum will have to be learned at somebody else's feet.
-Erwin Chargaff
Heraclitean Fire: Sketches from a Life before Nature
Posted by JP at 1:24 PM 0 comments
Friday, April 8, 2011
Islands
Posted by JP at 10:45 PM 0 comments
Labels: environment, evolution, Term 5, usmle
Tuesday, April 5, 2011
Celiac without the Celiac
Exam week here. Pathophysiology was yesterday, lots of confusing questions about GI and Heme, like patients with celiac that had Iron and B12 deficiency (...??) and nonanisopoikilocytosis (seriously?) but otherwise a doable exam. I did several hundred questions and started to get a sense of how different QBanks have different styles. Exammaster makes it too easy by putting things that have nothing to do with each other for answer options and many first order questions, though they have good explanations. Kaplan QBook does a better job of making the choices more difficult, but still remains pretty straightforward. UWorld is the most dificult, but you're always clear about what they want - just you don't know the answer most of the time.
Posted by JP at 5:04 PM 0 comments
Thursday, March 24, 2011
Patients Lie
Posted by JP at 6:06 PM 2 comments
Labels: Grenada Hospital Rotations, Term 5
Saturday, March 19, 2011
Reboot and Open Access
My guilty spiral of not posting, and then having things to post but not enough mental energy/time, seemed to be stalled in a perpetual procrastination spiral, but then I ran across a fellow med student blogger - Lex MD - and realized that I don't need to write paragraphs of detail about, well, studying without internet (it really works - thank you silly campus Bradford security restrictions!) in order to keep things going here - or at my other neglected blog with Global Pulse Journal (though I have been keeping up with the twitter account). So even with Step 1 slowly creeping towards me, I hope to have a little more of a social-net presence.
Posted by JP at 10:04 PM 0 comments
Labels: journals, open access, Term 5
Tuesday, January 18, 2011
MS2
Med school is about not giving up on things.
Sunday, November 28, 2010
Brain Off
I think my brain just turned off. This term is all about perservering and effeciency and not burning out. But when you can only concentrate for 20 minutes and then need 2 hours to recover - well, welcome to term 4.
Posted by JP at 10:50 AM 0 comments
Labels: blogs, globalpulse, life?, term 4
Tuesday, September 28, 2010
The Dengue
Dengue has struck Grenada in full force. The week before the Microbiology midterm, Prof. L, who was lecturing on Dengue, got the Dengue. Some classmates got it. Then this week, my lab partner gets it. Dear God, what is going on here!!
Posted by JP at 7:36 PM 0 comments
Tuesday, September 7, 2010
You wouldn't like me when I'm Angry
4 weeks into term 4. This semester is going fast... and you really have to spend every minute just to keep up. My little sleep/workout experiment continues - I managed to consistently get up a few minutes before 6 - though exhaustion has keep me in bed until about 6:15am these days...
Posted by JP at 6:48 AM 0 comments
Tuesday, August 10, 2010
Term 3: A tale of two terms
I arrived in Grenada with something less than rampant enthusiasm for class. Starting a term at the end of June just felt too much like summer school - even though it is summer weather here all the time. My concentration wasn't where it needed to be and I slept late, played on facebook, and generally didn't get a lot done (adjustment disorder?).
Posted by JP at 4:13 AM 1 comments
Labels: exercise, mornings, sleep schedule, term 3
Friday, July 30, 2010
Swing on the Spiral
Looking forward, while looking back and spinning while standing in place.
Posted by JP at 5:31 PM 0 comments
Labels: chip, fellowship, term 2, term 3
